|
How
other clients have benefited
In Drug Discovery:
-
Several chemical series were
prioritized according to their potential to yield drug-like leads
for an anti-cancer target
-
The binding mode, structure-activity
relationships and likely sites of off-target binding were elucidated
for two leading chemical series
-
Predicted off-target binding was
experimentally verified for several key cross-reactivity sites
-
Testing strategies were designed and
implemented for efficient prioritization of new compounds and
minimization of off-target interactions
-
New analogs with improved selectivity
for the desired target were identified
-
Patent applications were carefully written,
Examiner concerns were addressed and patents were issued
In Drug Development:
-
Chemistry, Manufacturing and Controls
(CMC) documents were provided in support of Investigational New Drug
Application (IND), New Drug Application (NDA), and postapproval
change filings
-
Chemistry concerns raised by
regulatory agencies were successfully addressed; one drug received
U.S. marketing approval
-
Technical challenges were solved in
active pharmaceutical ingredient (API) synthesis
-
API manufacturing costs were reduced
-
Toxic and environmentally hazardous
chemistry was eliminated from an API synthetic process
To learn about our other
service offerings, click here.
|
